Endocrine Abstracts

Introduction: Mechanism underlying glucose-mediated development and progression of diabetic complication are incompletely understood. Atrial natriuretic peptide (ANP) is a hormone released by atrial myocytes in response to acute and chronic extracellular volume expansion. Moderate hyperglycaemia (>400 mg/dl) in diabetic rats is associated with an elevation in circulating ANP levels and in GFR (glomerular filtration rate), (1) and play a role in the development of microalbu...

Objective: To compare the effects of a classic therapy to those of a novel treatment for androgen excess in adolescent girls.Study design: Randomized, open-labeled trial over 12 months.Study participants: Adolescents (n=34; mean age 16 year, BMI 23 kg/m2) with hyperinsulinemic androgen excess and without risk of pregnancy.Interventions: Ethinyl estradiol-cyproterone acetate (EE-CA; Diane 35 ...

Objective: To characterize the age variations of fatness pattern in Spanish womenResearch methods and procedures:: A cross-sectional study of 2226 Spanish women (16 to 74 years old) women was undertaken to study age variations in adiposity, body composition, obesity and central fat distribution. The women were divided into seven groups: Group I (G I, 15–24 years), Group II (G II, 25–34 years), Group III (G III, 35–44 years), Group IV (G IV...

Introduction: About 30% of all familial isolated pituitary adenoma (FIPA) and 50% of acromegaly families have a mutation in the aryl hydrocarbon receptor-interacting protein gene (AIP; Chahal, TEM, 2010). The functional role of AIP in somatotroph cells is unknown. Recently, it has been proposed that wild type AIP (wtAIP) is a tumor suppressor gene, role that is lost in the different mutant AIPs (mAIP; Leontiou, JCEM, 2008). In the adenomas, mAIPs are usually foun...

Background and aims: Use of potassium iodide (PI) supplements during gestation in mild to moderate iodine deficiency areas remains a controversial issue.Objective: Comparing the pharmacological effect of iodized salt versus iodide potassium supplements on the maternal thyroid function and neurodevelopment (Bayley Scales) of the progeny.Methods: One hundred and thirty one pregnant women were included from the first trimester (below ...

Introduction: Thyroid autoimmunity is related to iodine supply. Iodine nutrition has improved in our country, but the prevalence of autoimmune thyroiditis in our children is unknown.Objectives: To determine the status of iodine nutrition in children and adolescents in our city. To calculate local prevalence of thyroid autoimmunity and autoimmune thyroiditis in pediatric ages.Design: Cross-sectional epidemiological study.<p clas...

There is a clear relationship between degree of obesity and abdominal obesity with the development of cardiovascular disease.Objective: To assess body mass index (BMI) and waist circumference (WC) as predictors of cardiovascular risk (CVR) in type 2 diabetes mellitus (T2DM) patients.Material and Methods: Cross-sectional study in 452 consecutive out-patients with T2DM who visited our clinic in Madrid, Spain for a routine follow-up. ...

Androgen deficiency in the aging male has become an actual topic due to the aging population and finding from different studies that shown a progressive decline of serum levels of age-related testosterone. These levels have been inversely related with markers of metabolic syndrome and cardiovascular disease.The aim of this observational study was to investigate the relation of endogenous testosterone and other sex hormones with different components of me...

Understanding how fate choices are made by multipotent progenitors during pancreas development is valuable information in the quest for regenerative medicine and cell therapy to treat diabetes mellitus. Pancreatic differentiation is well defined and understood in rodents however, human data are comparably scarce. Specifically, when human pancreatic progenitors are multipotent is unknown as are the epigenetic changes that these cells undergo during their differentiation to beta...

Objective: An adequate thyroid function during pregnancy is essential for the normal brain development of the foetus, and some organochlorine compounds (OCs) can interfere with the thyroid system. The objective of the present study was to evaluate the association between exposure to some OCs and thyroid function in pregnant women from two different areas in Spain, as well as to investigate the potential confounding effect of iodine intake.Methods: Thyroi...